What are the consequences of indeterminate results in confirmatory tests for antibodies against transmissible viruses?

Evaluation of HIV Indeterminate Confirmatory Tests\' Results in Blood Donors in Northeast of Iran

Background and Aims: Human Immunodeficiency virus (HIV) is spreading rapidly among the people worldwide. Infection with this virus leads to immune suppression and finally acquired immune deficiency syndrome. Early HIV detection is dependent on antibody screening against virus by Enzyme Linked Immunosorbent Assay (ELISA). Some confirmatory tests such as Western Blot and Recombinant Immunobl...

HIV Indeterminate Western Blot Results in Blood Donors in Northeast of Iran, 2009-2014

Background and Aims: HIV is spreading rapidly among people word wide. Infection with this virus leads to immune suppression and finally acquired immune deficiency syndrome (AIDS).Early HIV detection is depended on antibody screening against virus by Enzyme Linked Immunosorbent Assay (ELISA).Some confirmatory tests such as Western Blot and Recombinant Immunobloting Assay (RIBA), are used to ve...

Interpretation of Serologic Test Results and Evaluation of Humoral Immune Response After Vaccination Following Infection with COVID-19 Disease

SARS-CoV-2 virus infection induces a cellular and humoral mediated immune response and produces antibodies against viral antigens such as nucleocapsid (N) protein and spike (S) protein. Anti-protein S antibodies also target the spike protein subunit S1 and the receptor binding domain (RBD). Serologic tests can detect the presence of these antibodies in blood serum within a few days to a few wee...

Development of a Western Blot Assay for Detection of Antibodies against HSV Using Purified HSV Virions Prepared by Sucrose Density Gradient

Objective(s) Herpes simplex viruses (HSVs) have widespread and ubiquitous prevalence in the human population and they have received a great deal of attention due to the range of diseases, they caused as a result of an infection. It seems that the fast and reliable diagnostic methods are needed for detecting the herpes simplex virus type 1 (HSV1) antibodies especially in patients with HSV encep...

Seroepidemological Survey for Antibodies against Infectious Bovine Rhinotracheitis and Bovine Herpes 4 Viruses among Cattle in Different Provinces of Iran.